BCQs of Pharmacokinetics and pharmacodynamics part -2

Q1: Pharmacokinetics include which of the following?

(a) Drug biotranformation in the organism

(b) Influence of drugs of genes

(d) Influence of drug on metabolism procss

Answer ~ A

Q2: Pharmacokinetics include :

(a) Interaction of substances

(b) Localization of drug action

(d) Excreation of substances

Answer ~ D

Q3: Pharmacokinetics include :

(a) Unwanted effects of drugs

(b) Pharmacological effects of drugs

(d) Chemical structure of medical agent

Answer ~ C

Q4: Which kind of substances can not cross membrane by passive diffusion ?

(a) Hydrophobic substances

(b) Hydrophilic substances

(d) Lipid soluble

Answer ~ B

Q5: Pharamcokinetics parameter that reflects the effects of various factors on distribution of drug in body is:

(a) Realative volume of distribution

(b) Absolute volume of distribution

(d) Apparent volume of distribution

Answer ~ A

Q6: Favourable route of administration for heparin is:

(a) Oral

(b) Intravenous

(d) Topical

(e) Subcutaneous

Answer ~ E

Q7: Hydrophilic medicinal agent has the following property :

(a) Low ability to penetrates through cell membrane

lipids

(b) Easy permeation through blood brain barrier

(d) Penetrates through membrane by means of

endocytosis

Answer ~ A

Q8: “Bioavailability” is the term which means :

(a) Permeability through blood brain barrier

(b) Plasma protein binding the drgree of substance

(d) Amount of substance in urine relative to initial dose.

Answer ~ C

Q9: Which is true regarding bioavailability :

(a) Ratio of amount of drug administered to amount absorbed in systemic circulation.

(b) Ratio of amount of drug absorbed in portal circulation to amount administered.

adminstered.

(d) Ration if amount of drug metabolised to amount

administered.

(e) Ratio of amount of drug absorbed in systemic circulation to amount adminstered.

Answer ~ E

Q10: Regafing bioavailability all are true except :

(a) It is the ratio of amount of drug absorbed in systemic circulation to amount administered.

(b) Bioavailability of intramuscular ratio is less than intravenous route.

(d) Two drugs have similar bioavailability when adminstered orally.

Answer ~ D

Q11: Reasons for determinig bioavailability are :

(a) Extent of absorption and hepatic first pass effect

(b) Glomerular filteration rate

(d) Amount of substance obtained orally and quantity of intakes.

Answer ~ A

Q12: Parental administration :

(a) Can’t be used with unconscious patient

(b) Is too slow fro emergency use

(d) Usually produce more rapid response than oral administration.

Answer ~ D

Q13: Parental route of drug administartion is :

(a) Intrathecal

(b) Sublingual

(d) Rectal

Answer ~ A

Q14: What is the characteristics of intramuscular route of drug administration?

(a) Oily solutions can be injected

(b) Only water solution can be injected

(d) The action develops slower than oral

administration.

Answer ~ A

Q15: Which of the following is not Biological barrier :

(a) Cell membrane

(b) Capillaries

(d) Placenta

Answer ~ C

Q16: Component if biological system to which drug binds to bring about change in function of system is :

(a) Receptor

(b) Effector

(d) Inner binding site

Answer ~ A

Q17: Component of the biological system to which drug binds without changing in function of it’s :

(a) Spare receptor

(b) Inner binding site

(d) Transport channel

(e) Enzymes

Answer ~ B

Q18: The volume of distribution(Vd) relaltes :

(a) An administered dose in body weight

(b) Single to a daily dose of an adminstered drug

(d) The amount of drug in the body to the concentration of drug in plasma.

Answer ~ D

Q19: Biotransformation means :

(a) Process of physiochemical and biochemical alteration of drug in body.

(b) Binding of substance with plsma protein

(d) Accumulation of substance in tissue

Answer ~ A

Q20: An antagonist is the substance that:

(a) Bind to receptor and initiates changes in cell

function, producing maximal effect.

(b) Binds to receptor and initiates changes in cell

function, producing submaximal effect.

produce any effect.

(d) Binds to receptor without directly altering their

function.

Answer ~ D

Q21: An competitive antagonists is a substance that:

(a) Interact with receptor and produce submaximal effect.

(b) Binds to the same receptor site and progessively inhibits the agonists response.

(d) Binds to one receptor subtype as an agonist and to another as an antagonists.

Answer ~ B

Q22: The substance binding to one receptor subtype as an agonists and to another as an antagonists is :

(a) Competitive antagonist

(b) Irreversible antagonist

(d) Partial agonist

(e) Partial antagonist

Answer ~ C

Q23: Which of the following substance whose mechanisms are based on interaction with ion channels :

(a) Calcium channel blocker

(b) Sodium channel blocker

(d) All of them

Answer ~ D

Q24: Half life is the time required :

(a) Metabolise a half of an introduced drug in plasma by half during elimination.

(b) Change the amount of drug in plasma by half during elimination.

(d) Binds half of an introduced drug to plasmaprotein.

Answer ~ B

Q25: Half life doesn’t depend upon :

(a) Biotransformation

(b) Time of drug absorption

(d) Rate of drug elimination

Answer ~ B

Q26: Elimination is expressed as follows :

(a) Rate of renal tubule reabsorption.

(b) Time required to decrease the amount of drug in plasma by one half.

(d) Clearance of an organism from a xenobiotics.

Answer ~ D

Q27: Systemic ckearance is related with :

(a) Only the concentration of substance in plasma.

(b) Only the elimination rate constant.

(d) Bioavailability & half life.

Answer ~ C

Q28: Acetaminophen undergoes which type of phase 1 reactions :

(a) Deamination

(b) S-oxidation

(d) Dehydrogenation

(e) Alkylation

Answer ~ C

Q29: If 1mg if lorazepam produce the same anxiolytic response as 10mg of diazepine, which is correct?

(a) Lorazepam is more potent than diazepine.

(b) Lorazepam is more effectious than diazepine.

(d) Lorazepam is a better drug to take for anxiety than is diazepam.

Answer ~ A

Q30: With IV infusion, a drug reaches 50% of it’s final steady state in 6 hours. The elimination half life of the drug must be approximately:

(a) 2h

(b) 6h

(d) 24h

(e) 30h

Answer ~ B

Comments

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