DRUG DISTRIBUTION       • Drug distribution is the process by which the drug reversibly leaves the blood stream and enters the extracellular fluid and tissues.    - For drugs administered IV, absorption is not a factor and the initial phase immediately following administration represents distribution phase.   - The distribution of the drug from plasma to interstitium depends upon :        (i) cardiac output & local blood flow       (ii) capillary permeability       (iii) degree of binding of drug to plasma & tissue protein       (iv) lipophilicity of drug       (v) Volume of distribution    (1) Blood flow :   • The rate of blood flow to the tissue capillaries varies widely. For instance, blood flow to vessel rich organs (like : brain, liver & kidney) is greater than skeletal muscles, adipose tissues, skin which have lower rates of blood flow....