Drug Clearance It refers to the ratio of rate of drug elimination to the concentration of drug in biological fluid(C).                       CL = rate of elimination / C Rate of elimination   • For most of the drugs, elimination is not saturable & rate of drug elimination is directly proportional to concentration.                     Rate of elimination = CL x C ==> The difference between drug clearance and drug elimination is that :     • Clearance is Volume of blood cleared of drug per unit time and Elimination is amount of drug cleared from blood per unit time.  Total Body Clearance   • The total body systemic clearance , CLtotal is the sum of all clearances from drug metabolising and drug eliminating organs.                                      ...